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Originally published August 4, 2022
Last updated June 29, 2025
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Pancreatic cancer has a bad reputation β and for good reason. Pancreatic cancer is the third leading cause of cancer-related death in the United States, after lung and colon, according to the .
βThere are very few early warning signs of pancreatic cancer, which makes it difficult to diagnose in its initial stages,β says Heinz-Josef Lenz, MD, an oncologist with the ίχίδΙηΗψ Norris Comprehensive Cancer Center, part of ίχίδΙηΗψ.
Plus, the location of the pancreas makes it hard for doctors to feel tumors during regular checkups. The pancreas is located deep within your body, in between your stomach and spine. Oftentimes, this means the cancer isnβt found until the cancer has spread, which makes it harder to treat. While the symptoms of pancreatic cancer can be tough to identify, Dr. Lenz shares seven signs to be on the lookout for and bring to your doctorβs attention.
One of the most common of pancreatic cancer is . This is a condition that turns the whites of your eyes and skin yellow due to a buildup of bilirubin, a yellow substance made in the liver.
βWhen a tumor grows on the pancreas, it pushes on your bile duct system, leading to a blockage that causes a backup of bile and what we can see as jaundice,β says Dr. Lenz.
If cancer starts in the βheadβ of the fish-shaped pancreas, jaundice may occur when the tumor is still small and at an early stage.
The same buildup of bilirubin that can cause jaundice may also trigger another possible telltale sign of pancreatic cancer: itchy skin.
Itchy skin, or , that doesnβt have a clear cause or doesn’t go away after a few weeks is a symptom you should discuss with your doctor.
A change in the color of urine or stool is yet another bilirubin-related issue that may be a symptom of pancreatic cancer. βYou may have darker pee and paler stool than usual,β Dr. Lenz says.
Excess bilirubin can turn urine a brownish color. A blockage of bilirubin, however, can result in lighter-colored stool.
βPancreatic cancer can prevent the proper enzymes from getting to the intestines and breaking down fat, making stool appear greasier,β he says.
Pancreatic cancer may also lead to digestive issues or sudden, unexplained weight loss. βIf pancreatic juices donβt flow, digestion is not complete, which can cause bloating, lack of appetite and weight loss, when youβre not trying to shed pounds,β Dr. Lenz says. If a tumor is pressing on the stomach, you may also experience nausea and vomiting.
Another symptom to be on the lookout for is pain in the abdomen or back. This type of discomfort is more likely to occur when the cancer develops in the βbodyβ or βtailβ area of the pancreas.
βIf a tumor is in the body or tail of the pancreas, symptoms may appear much later,β Dr. Lenz says. βThis means the tumor may grow large, before you feel pain or discomfort in your abdomen or back.β
He recommends getting a checkup if you experience any unexplained abdominal pain lasting for more than one to two weeks.
For some people, may be the first sign of pancreatic cancer. It may present as a blood clot in the leg, called a (DVT). Or it could be a (PE), a blood clot that occurs in the lungs.
βEven though blood clots may be a sign of pancreatic cancer, they are more often caused by other health conditions,β Dr. Lenz says.
Pancreatic cancer can disrupt insulin production, which can lead to a sudden onset of diabetes, according to the . Generally, diabetes develops over time, so itβs important to get checked by your doctor if youβre experiencing the sudden onset of symptoms.
Because itβs so hard to find the disease early, if you do have signs of pancreatic cancer, itβs important to get checked out right away.
βIf any of the symptoms described show up and persist for more than one week, you need to see a doctor,β Dr. Lenz says.
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