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Originally published November 7, 2024
Last updated July 1, 2025
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As women go through menopause, some men may go through a similar experience called andropause, which results from a decrease in their natural testosterone production. There are many therapies on the market for men in this stage of life, but the only one meant to be prescribed and monitored by a doctor is testosterone replacement therapy.
While general awareness and understanding of testosterone replacement therapy has improved in recent years, many people still have questions. Is testosterone replacement therapy safe? What are the side effects of testosterone replacement therapy? How is testosterone replacement therapy different from over-the-counter drugs and supplements?
Kian Asanad, MD, a urologist specializing in men鈥檚 health at 喵咪社区 Urology, part of 喵咪社区, answers these questions and more.
Some studies suggest that testosterone begins to dip between the ages of 40 and 60, and the most common symptoms include:
However, other conditions, such as underlying depression or stress, can also cause these symptoms.
鈥淚t鈥檚 a good idea to see a doctor for a two-part blood test to confirm the diagnosis,鈥 Dr. Asanad says.
He adds that newer studies have demonstrated that it is actually the accumulation of other medical problems as men get older (such as diabetes, high blood pressure, obesity and metabolic syndrome) that results in decreased testosterone levels. In other words, if men stay healthy as they get older, they can maintain normal testosterone levels as they age.
Over-the-counter testosterone remedies commonly advertised on TV are mainly vitamin and herbal supplements. However, a prior study has found that some of these supplements actually do contain testosterone or testosterone precursors, which should only be taken under a doctor鈥檚 supervision.
鈥淓xogenous testosterone therapy can make men infertile and lower their sperm counts,鈥 Dr. Asanad says. 鈥淪o, if a 35-year-old man is thinking, 鈥業 need an energy booster鈥 and starts taking a testosterone therapy from the plethora of online direct-to-consumer platforms available, it could seriously affect their fertility. Without appropriate counseling, they may not be aware that their sperm count has gone down.鈥
He adds, 鈥淚n cases where men want to preserve their fertility potential, I recommend alternative testosterone therapies, such as clomiphene citrate, which help boost natural testosterone production.鈥
鈥淣o,鈥 Dr. Asanad says. 鈥淎n FDA study has concluded that testosterone replacement therapy does not increase a patient鈥檚 risk of developing prostate cancer.鈥
That doesn鈥檛 mean everyone can or should use it, though.
鈥淚f someone is currently living with low-risk prostate cancer or they had a history of prostate cancer and it has been completely treated, testosterone replacement therapy is more nuanced and complex. This should typically only be prescribed and monitored by their urologist,鈥 Dr. Asanad says.
Testosterone replacement therapyis most commonly given as a topical gel or an injection, though 鈥渢here鈥檚 also pellet therapy and newer oral testosterone agents,鈥 Dr. Asanad says. As a result, men can choose whatever form of therapy best suits their lifestyle.
Dr. Asanad wants every patient to know that a urologist鈥檚 office 鈥渋s a very safe space.鈥 There鈥檚 not much your urologist hasn鈥檛 seen.
He adds, 鈥淢any men suffer from low testosterone, and it can significantly impact their quality of life.鈥
The good news is, low testosterone is easily treated, with many different options available to suit each patient鈥檚 unique needs and life goals.
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